Urinary albumin detection based on surface plasmon resonance sensor

CHEN Meng-meng; XIONG Xing-liang; LI Guang; ZHANG Ting-ting; CHEN Zhen

doi:10.13873/j.1000-97872014.06.044

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Urinary albumin detection based on surface plasmon resonance sensor

更新时间：2025-09-11

- Urinary albumin detection based on surface plasmon resonance sensor
- Vol. 33, Issue 6, Pages: 120-121+125(2014)
- 作者机构：
  
  重庆医科大学生物医学工程研究室
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-97872014.06.044
  CLC： TP212
- Published：2014
- 稿件说明：
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[1]陈萌梦,熊兴良,李广,张婷婷,陈镇.基于表面等离子体共振传感器的尿微量白蛋白检测[J].传感器与微系统,2014,33(06):120-121+125.

CHEN Meng-meng, XIONG Xing-liang, LI Guang, et al. Urinary albumin detection based on surface plasmon resonance sensor[J]. 2014, 33(6): 120-121+125.
[1]陈萌梦,熊兴良,李广,张婷婷,陈镇.基于表面等离子体共振传感器的尿微量白蛋白检测[J].传感器与微系统,2014,33(06):120-121+125. DOI： 10.13873/j.1000-97872014.06.044.

CHEN Meng-meng, XIONG Xing-liang, LI Guang, et al. Urinary albumin detection based on surface plasmon resonance sensor[J]. 2014, 33(6): 120-121+125. DOI： 10.13873/j.1000-97872014.06.044.

摘要

检测尿微量白蛋白（MAU）可对轻微肾脏损害进行早期诊断

也可对高血压患者可能发生的心脑血管事件进行预测。实验将抗体通过巯基自组装固定于Au膜表面

研制了一种快速检测MAU的表面等离子体共振（SPR）生物传感器。结果表明:直接检测法可以检测到0.3μg/L的MAU

而纳米Au放大法检测限可以低至0.03μg/L。

Abstract

The detection of urinary albumin（ MAU） is significant for early diagnosis for early renal damage and predicting cardio-cerebral-vascular disease of hypertension patients. Antibody is fixed on Au film surface by selfassembled monolayers

develop a surface plasmon resonance（ SPR） biosensor for rapid detection of MAU. Results show that direct detection method can detect MAU of 0. 3 μg / L

while

as to detection limit of Au nanoparticle amplification method

can be as low as 0. 03 μg / L.

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references

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Sensitivity enhancement of SPR assay of progesterone based on mixed self-assembled monolayers using nanogold particles [J] . J. Yuan,R. Oliver,J. Li,J. Lee,M. Aguilar,Y. Wu. Biosensors and Bioelectronics . 2007 (1)

Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population [J] . Hans L. Hillege,Vaclav Fidler,Gilles F.H. Diercks,Wiek H. van Gilst,Dick de Zeeuw,Dirk J. van Veldhuisen,Rijk O.B. Gans,Wilbert M.T. Janssen,Diederick E. Grobbee,Paul E. de Jong. Circulation: Journal of the American Heart Association . 2002 (14)

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Enzyme immunoassay: an improved determination of urinary albumin in diabetics with incipient nephropathy [J] . Bo Feldt-Rasmussen,Bo Dinesen,Marja Deckert. Scandinavian Journal of Clinical & Laboratory Inv . 1985 (6)

Radioimmunoassay for Urinary Albumin Using a Single Antibody [J] . D. W. Miles,C. E. Mogensen,H. J. G. Gundersen. Scandinavian Journal of Clinical & Laboratory Inv . 1970 (1)

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