Design of a novel microfluidic system and rationality analysis

TANG Xiao-liang; SANG Sheng-bo; ZHANG Wen-dong; LI Peng-wei; HU Jie; LI Gang

doi:10.13873/j.1000-97872014.03.042

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Design of a novel microfluidic system and rationality analysis

更新时间：2025-09-11

- Design of a novel microfluidic system and rationality analysis
- Vol. 33, Issue 3, Pages: 114-117(2014)
- 作者机构：
  
  1. 太原理工大学微纳系统研究中心
  2. 太原理工大学新型传感器与智能控制教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-97872014.03.042
  CLC： TP273
- Published：2014
- 稿件说明：
移动端阅览
[1]唐晓亮,桑胜波,张文栋,李朋伟,胡杰,李刚.一种新型微流体系统设计与合理性分析[J].传感器与微系统,2014,33(03):114-117.

TANG Xiao-liang, SANG Sheng-bo, ZHANG Wen-dong, et al. Design of a novel microfluidic system and rationality analysis[J]. 2014, 33(3): 114-117.
[1]唐晓亮,桑胜波,张文栋,李朋伟,胡杰,李刚.一种新型微流体系统设计与合理性分析[J].传感器与微系统,2014,33(03):114-117. DOI： 10.13873/j.1000-97872014.03.042.

TANG Xiao-liang, SANG Sheng-bo, ZHANG Wen-dong, et al. Design of a novel microfluidic system and rationality analysis[J]. 2014, 33(3): 114-117. DOI： 10.13873/j.1000-97872014.03.042.

摘要

微流体系统作为一种可对流体进行精密控制、操作与检测的技术

其发展为细胞体外培养提供了新的平台

而且可与生物传感器结合构成微流体传感测试系统

大大提高细胞传感检测的精确性、一致性和稳定性。在微系统设计与制造的基础上

提出了一种新型微流体系统结构

应用COMSOL软件建立了微流体系统模型

通过对其流动特性的分析对比

优化了系统结构

系统地研究了其对细胞培养与检测的影响。结果表明:该结构既能实现细胞的长期培养;又能通过精确的微流控制

结合生物传感器

对不同时期或不同病态的细胞进行实时检测和分析。该研究对医用药物测试芯片与微流传感测试系统有着重要的意义。

Abstract

Microfluidic system as a kind of technology which can deal with fluids with precise control

manipulation and testing

its development provides a new platform for cells cultivation in vitro and it can constitute microfluidics sensing and test system by combining with biosensor

which can greatly improve the accuracy

consistency and stability of cell sensing test.On the basis of microsystem design and fabrication

a novel microfluidic system structure is proposed

and its model is built with the COMSOL software.By analyzing and comparing its flow characteristics

system structure is optimized

and the influences on cell cultivation and test are investigated systematically.Result indicates that

this structure can not only achieve long-term cultivation of cells

but also can real-time detect and analyze cells in different periods or different physiological states by precise control

combine with biosensors.The research has great signficance in medical drug test chip and microfluidics sensing and test system.

关键词

Keywords

references

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