Development of a photon-counting detecting system with high precision based on FPGA

WANG Mi-xia1; LIU Jun-tao1; LIU Ru-ping1; LIU Xiao-hong1; CAI Xin-xia1

doi:10.13873/j.1000-97872011.02.021

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Development of a photon-counting detecting system with high precision based on FPGA

更新时间：2025-09-11

- Development of a photon-counting detecting system with high precision based on FPGA
- Vol. 30, Issue 2, Pages: 20-22(2011)
- 作者机构：
  
  1. 中国科学院电子学研究所传感技术联合国家重点实验室
  2. 中国科学院研究生院
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-97872011.02.021
  CLC： TN911.23
- Published：2011
- 稿件说明：
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[1]王蜜霞,刘军涛,刘儒平,刘晓红,蔡新霞.基于FPGA的高精度光子计数检测系统研究[J].传感器与微系统,2011,30(02):20-22.

WANG Mi-xia1, LIU Jun-tao1, LIU Ru-ping1, et al. Development of a photon-counting detecting system with high precision based on FPGA[J]. 2011, 30(2): 20-22.
[1]王蜜霞,刘军涛,刘儒平,刘晓红,蔡新霞.基于FPGA的高精度光子计数检测系统研究[J].传感器与微系统,2011,30(02):20-22. DOI： 10.13873/j.1000-97872011.02.021.

WANG Mi-xia1, LIU Jun-tao1, LIU Ru-ping1, et al. Development of a photon-counting detecting system with high precision based on FPGA[J]. 2011, 30(2): 20-22. DOI： 10.13873/j.1000-97872011.02.021.

摘要

为了实现微弱光信号的高精度检测

设计了一种基于现场可编程门阵列（FPGA）的光子计数检测系统。采用高灵敏度的光电倍增管作为光电转换器件

有效地实现微弱光信号的获取与处理。基于FP-GA

设计了时序控制模块、光子计数模块、串口通信模块、存储模块和键盘扫描控制模块

完成信号的处理与存储。使用该系统对三磷酸腺苷（ATP）样品进行生物发光测试

在ATP浓度为2.5×10-14

.5×10-8mol/L范围内

系统检测光强与ATP浓度之间线性关系良好

相关系数R=0.983 2;对碱性磷酸酶（ALP）化学发光体系进行测试

在ALP浓度为2.5×10-12

×10-9mol/L范围内

系统检测光强与ALP浓度之间线性关系良好

相关系数R=0.998 2。该检测系统小型便携

检测精度高

在低浓度生物活性物质检测领域具有广阔的应用前景。

Abstract

In order to measure weak optical signal

a photon-counting detecting system based on FPGA is designed and constructed.A high sensitivity photomultiplier tube（PMT）is used to obtain the optical signal.The system consists of time scheduling control module

photon-counting module

serial communication module

memory module and key-scanning control module.Adenosine triphosphate（ATP）samples with concentration of 2.5×10-14～2.5×10-8 mol/L are measured and the correlation coefficient between ATP concentration and light intensity is 0.9832.Alkaline phosphatase（ALP）samples with concentration of 2.5×10-12～5×10-9mol/L is measured and the correlation coefficient between ALP concentration and light intensity is 0.9982.The system has the characteristics of small size

high precision

and is easy to operate.It can be widely used in detection of low concentrations of substances.

关键词

Keywords

references

高灵敏度化学发光磁酶免疫法检测人绒毛膜促性腺激素 [J]. 刘军涛,刘儒平,王蜜霞,刘春秀,罗金平,蔡新霞. 分析化学 . 2009(07)

基于Virtex-4 FPGA的低功耗图像融合系统 [J]. 宋亚军,许廷发,倪国强,高昆,王强. 光学精密工程 . 2007(06)

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