Study on practicality of micro-channel measurement system for red blood cell deformability

ZHENG Xiao-lin1; CHANG Jing1; LIAO Yan-jian1; YANG Jun1; LIU Chang1

doi:10.13873/j.1000-97872009.07.002

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Study on practicality of micro-channel measurement system for red blood cell deformability

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- Study on practicality of micro-channel measurement system for red blood cell deformability
- Vol. 28, Issue 7, Pages: 117-120(2009)
- 作者机构：
  
  1. 重庆大学生物工程学院
  2. 新型微纳器件与系统技术国家重点学科实验室
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-97872009.07.002
  CLC： R318.0
- Published：2009
- 稿件说明：
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[1]郑小林,常婧,廖彦剑,杨军,刘畅.硅微通道红细胞变形性测量系统的实用化研究[J].传感器与微系统,2009,28(07):117-120.

ZHENG Xiao-lin1, CHANG Jing1, LIAO Yan-jian1, et al. Study on practicality of micro-channel measurement system for red blood cell deformability[J]. 2009, 28(7): 117-120.
[1]郑小林,常婧,廖彦剑,杨军,刘畅.硅微通道红细胞变形性测量系统的实用化研究[J].传感器与微系统,2009,28(07):117-120. DOI： 10.13873/j.1000-97872009.07.002.

ZHENG Xiao-lin1, CHANG Jing1, LIAO Yan-jian1, et al. Study on practicality of micro-channel measurement system for red blood cell deformability[J]. 2009, 28(7): 117-120. DOI： 10.13873/j.1000-97872009.07.002.

摘要

针对硅微通道红细胞变形性测量系统的实用化关键性技术

包括小型化、集成化和操作的规范性、简便性等方面进行研究。利用聚二甲基硅氧烷（PDMS）进行芯片和流路接口的一次性封装

使芯片测量部分整体成型。另外

将系统的进样驱动改进为恒流源

采用注射泵控制

使系统更易实现

且提高了进样的稳定性。针对改进系统的初步实验表明:恒流驱动具有良好的稳定性

在一定程度上更接近人体微循环毛细血管环境

系统操作简便

增加了红细胞变形性分析的可靠性。

Abstract

The critical technology related to the practicality of micro-channel measurement system for red blood cell（RBC）deformability is investigated

in terms of miniaturization

integration

especially the normative and convenient operation.Two improvements are made on the system.The original silicon chip and the flow paths are packaged in a single chip by the use of PDMS to realize the plug and play function.The injection pump is used for the sampling and flow driving to improve the stability of sample injection.The preliminary experiment results show that the system in the constant flow driving mode is more stable

more suitable to simulate the Human capillary microcirculation environment and more reliable for analysis of red blood cell deformability.

关键词

Keywords

references

基于MEMS技术的红细胞变形性测量系统的研究 [J]. 姜海,郑小林,彭承琳,翁璇. 中国医疗器械信息 . 2006(12)

聚二甲基硅氧烷微流体芯片的制作技术 [J]. 刘长春,崔大付,王利. 传感器技术 . 2004(07)

硅微通道法测量红细胞变形性的双参数模型 [J]. 廖彦剑,郑小林,张文献,彭承琳. 北京生物医学工程 . 2002(04)

一种新的硅微通道红细胞变形性测量方法 [J]. 郑小林,吴楠,卢晓,蔡绍皙,吴云鹏,彭承琳,何林,胡刚毅,郑娥,崔茂镜. 中国生物医学工程学报 . 2000(01)

内皮细胞对扰动剪切流场响应的研究 [D]. 韩亚刚. 重庆大学 2006

生理学[M]. 人民卫生出版社 , 姚泰主编, 2003

细胞流变学[M]. 科学出版社 , 胡金麟主编, 2000

生物流变学[M]. 科学出版社 , [日]冈小天著, 1988

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