A high sensitive readout circuit for self-assembly biosensor micro arrays is designed.The circuit includes a high sensitive biologic current detection unit for micro arrays

integration unit

correlated double sampling（CDS） unit and output buffer unit.The circuit with a single 5 V power supply can accept very weak input current in a range of 0

5

0 nA.Simulation is carried out with 0.6 μm/level 7 CMOS process

and a good simulation result is achieved.The circuit is compatible with a standard CMOS process to realize an integrated biosensor array.