Microdialysis glucose sensor based on co-immobilizing technique

WANG Zhong; YU Ping

doi:10.13873/j.1000-97872003.02.021

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Microdialysis glucose sensor based on co-immobilizing technique

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- Microdialysis glucose sensor based on co-immobilizing technique
- Issue 2, Pages: 58-60+64(2003)
- 作者机构：
  
  1. 浙江大学生物医学工程与仪器科学学院国家传感器专业实验室
  2. 浙江大学生物医学工程与仪器科学学院国家传感器专业实验室,浙江,杭州,310027
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-97872003.02.021
  CLC： TP212.3
- Published：2003
- 稿件说明：
移动端阅览
[1]王钟,于平.基于双酶固定化技术的微透析葡萄糖传感器[J].传感器技术,2003(02):58-60+64.

WANG Zhong, 　YU Ping. Microdialysis glucose sensor based on co-immobilizing technique[J]. 2003, (2): 58-60+64.
[1]王钟,于平.基于双酶固定化技术的微透析葡萄糖传感器[J].传感器技术,2003(02):58-60+64. DOI： 10.13873/j.1000-97872003.02.021.

WANG Zhong, 　YU Ping. Microdialysis glucose sensor based on co-immobilizing technique[J]. 2003, (2): 58-60+64. DOI： 10.13873/j.1000-97872003.02.021.

摘要

建立了一个双酶葡萄糖传感器微透析系统

并且在体外实验中考察了影响系统响应结果的关键因素

即固定化酶膜技术和微透析系统的灌注速率。优化的系统采用夹心法固定化葡萄糖氧化酶和过氧化氢酶于金叉指电极

并采用20μl/min的灌注速率。系统具有良好的线性、灵敏度和响应时间。

Abstract

?A microdialysis glucose sensor system based on coimmobilizing technique has been developed

and factors crucial to the system’s response characteristics are evaluated in ex vivo experiments

namely

the immobilizing technique and the flow rate. The optimized system has adopted a graduated （"sandwich"） immobilizing method to coimmobilize glucose oxidase with peroxidase on the silicon wafer of Au interdigital electrode

and the flow rate is chosen to be at 20?μl/min.The system offers good linearity

fast response

and satisfactory sensitivity.

关键词

Keywords

references

PEG对SiO 2 溶胶-凝胶中颗粒度分布和孔结构的影响 [J]. 汤加苗,朱从善,夏海平,范文浩,吴东,孙予罕. 材料研究学报 . 1998(01)

超微电极电化学[M]. 科学出版社 , 张祖训著, 1998

In vivo measurement of subcutaneous glucose concentrations with an enzymatic glucose sensor and a wick method [J] . J. Brückel,W. Kerner,H. Zier,G. Steinbach,E. F. Pfeiffer. Klinische Wochenschrift . 1989 (9)

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