Resonant wireless biosensor for quantitative analysis on carcinoembryonic antigen

LI Ying-yin; SUN Hao; ZUO Zhao-rui; MAO Hong-ju; QIAN Da-hong

doi:10.13873/j.1000-9787(2018)06-0059-03

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Resonant wireless biosensor for quantitative analysis on carcinoembryonic antigen

更新时间：2025-09-11

- Resonant wireless biosensor for quantitative analysis on carcinoembryonic antigen
- Issue 6, Pages: 59-61(2018)
- 作者机构：
  
  1. 浙江大学医学院转化医学研究院
  2. 中国科学院上海微系统与信息技术研究所
  3. 上海交通大学生物医学工程学院
- 作者简介：
- 基金信息：
- DOI：10.13873/j.1000-9787(2018)06-0059-03
  CLC： TP212
- Published：2018
- 稿件说明：
移动端阅览
LI Ying-yin, SUN Hao, ZUO Zhao-rui, et al. Resonant wireless biosensor for quantitative analysis on carcinoembryonic antigen[J]. 2018, (6): 59-61.
DOI：

LI Ying-yin, SUN Hao, ZUO Zhao-rui, et al. Resonant wireless biosensor for quantitative analysis on carcinoembryonic antigen[J]. 2018, (6): 59-61. DOI： 10.13873/j.1000-9787(2018)06-0059-03.

摘要

提出一种可用于快速检测肿瘤标志物的谐振式无线生物传感器:采用微机电加工技术通过光刻、金属蒸发等加工工艺制备出含有电感电容单元的微电极结构

利用戊二醛共价修饰技术在传感器电极间隙特异性捕获肿瘤标志物癌胚抗原;改变传感器系统的参数

使得谐振系统带宽值发生变化

实现对癌胚抗原的定量检测分析。实验结果表明:研制的传感器能检测出修饰过程的细微变化

对于癌胚抗原的最低检测限度为1 ng/mL

检测范围为1

000 ng/mL

具有良好的特异性和灵敏度。研究为肿瘤愈后监测提供了便携、快速、低廉的检测方法。

Abstract

A resonant wireless biosensor for fast detection of tumor markers is put forward. Microelectrode structure with inductor and capacitor unit

which is produced by MEMS technology such as lithography

metal evaporation

modificated by glutaraldehyde to capture carcinoembryonic antigen in sensor electrode gap.Specifically

with the change of the parameters of sensor system

the resonance bandwidth value changes

so as to realize quantitative analysis on detection of carcinoembryonic antigen. The results show that the sensor can detect slight changes in the modification process. The minimum detection limit for CEA is 1 ng/ml

and detection concentrations range is 1

1 000 ng/ml

which has good specificity and sensitivity. This study provides

a portable

fast and cheap detecting method for tumor prognosis.

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