成都医学院公共卫生学院
Published：2024
移动端阅览
[J]. 2024, (1): 1-6.
基于外泌体的适配体传感器的检测方法具有快速、灵敏、高通量、无创或微创、液体活组织检查和经济高效的分析等诸多优势，成为近年研究热点。综述了目前适配体在检测外泌体、外泌体靶向递送领域的研究进展。首先，介绍了外泌体、适配体和适配体传感器，以及近年常用的适配体筛选技术；其次，阐述基于外泌体的适配体传感器的构建及原理、适配体在外泌体领域的应用；最后，针对目前适配体在外泌体应用领域提出了所遇到的问题和挑战。
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CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. xfang@iccas.ac.cn zhangzhen@iccas.ac.cn.,Department of Medical Oncology, Peking University International Hospital, Beijing 102206, P. R. China.,Echo Biotech Co. Ltd, Beijing 102206, P. R. China.,CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. xfang@iccas.ac.cn zhangzhen@iccas.ac.cn.,CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. xfang@iccas.ac.cn zhangzhen@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.,CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. xfang@iccas.ac.cn zhangzhen@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.,Echo Biotech Co. Ltd, Beijing 102206, P. R. China.,Echo Biotech Co. Ltd, Beijing 102206, P. R. China.,CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. xfang@iccas.ac.cn zhangzhen@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China..Aptamer-based fluorescence polarization assay for separation-free exosome quantification.[J].Nanoscale,2019.
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Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology , Beijing 100029, China.,Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, McKnight Brain Institute, UF Genetics Institute, University of Florida , Gainesville, Florida 32611-7200, United States.,Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University , Changsha 410082, China.,Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, McKnight Brain Institute, UF Genetics Institute, University of Florida , Gainesville, Florida 32611-7200, United States.,Department of Chemistry and 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