A nerve electrical signal recording and self-adjustable stimulation closed-loop system for Parkinson’s disease is proposed.The system consists of front-end acquisition module

which acquire neural signal;microprocessor is used as control system and can generate electrical stimulation pulses according to abnormal signal

and dual mode（constant voltage and constant current）stimulation circuit for self-adjustable electrical pulses stimulation.The system has the noise floor within 8 μV（RMS）.Sinusoidal signals 20 μV and simulated neural signal below 200 μV are measured.The voltage amplitude of output adjustable electrical stimulation pulses are in the range of 0～3.3 V or current of 0～1 mA

frequency of 0～1 kHz and the minimum pulse width of 1 μs.