In response to the growing demand for in-vitro diagnostics

the need for personalized care and the need for early detection of cancer

use difference circulating tumor cell（ CTC） and normal cell physical characteristics

through the microporous membrane and corresponding separation and enrichment of liquid path

the physical separation of specific cells and normal cells is realized. The liquid path pressure is simulated and analyzed by Fluent software. Aiming at the case that in the process of the liquid flow

the microporous membrane for blood component plug hole induced porosity decreases

causing the pressure into the microporous membrane bear a reasonable interval

and even lead to rupture of membranes blocked. A one-dimensional fuzzy control rule is proposed

which can make the pressure of the microporous filter stable within a reasonable range.