Design of circuit system for liquid phase QCM biosensor

JI Jun-wang; LU Wei-ping; XU Huan; YANG Cheng; HOU Chang-jun; CHEN Ming

doi:10.13873/J.1000-9787(2016)10-0070-03

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Design of circuit system for liquid phase QCM biosensor

更新时间：2025-09-11

- Design of circuit system for liquid phase QCM biosensor
- Vol. 35, Issue 10, Pages: 70-72(2016)
- 作者机构：
  
  1. 重庆大学生物工程学院
  2. 第三军医大学大坪医院检验科
- 作者简介：
- 基金信息：
- DOI：10.13873/J.1000-9787(2016)10-0070-03
  CLC： TP212.3
- Published：2016
- 稿件说明：
移动端阅览
[1]姬君旺,鲁卫平,徐欢,杨成,侯长军,陈鸣.液相QCM生物传感器电路系统设计[J].传感器与微系统,2016,35(10):70-72.

JI Jun-wang, LU Wei-ping, XU Huan, et al. Design of circuit system for liquid phase QCM biosensor[J]. 2016, 35(10): 70-72.
[1]姬君旺,鲁卫平,徐欢,杨成,侯长军,陈鸣.液相QCM生物传感器电路系统设计[J].传感器与微系统,2016,35(10):70-72. DOI： 10.13873/J.1000-9787(2016)10-0070-03.

JI Jun-wang, LU Wei-ping, XU Huan, et al. Design of circuit system for liquid phase QCM biosensor[J]. 2016, 35(10): 70-72. DOI： 10.13873/J.1000-9787(2016)10-0070-03.

摘要

设计的石英晶体微天平（QCM）仪器主要用于微量物质在液体中的生物化学反应的测量

根据液相QCM生物传感器的需要完成了电路系统部分的设计

选用Microchip的单片机为液相QCM生物传感器的电路系统的核心

主要包括电源部分、信号激励与接收部分、温控部分

实现了石英晶体的激励和频率的检测、温度的采集与控制等功能。上位机检测结果显示:实际温度控制精度误差为0.2℃

能顺利检测到最佳谐振频率

表明该系统能够较好地达到预期的要求。

Abstract

The designed quartz crystal microbalance（ QCM） instrument is to measure biochemical reactions of trace substances in liquid. The circuits system is designed according to requirements of liquid phase QCM biosensor

including power supply unit

signal excitation and receiving unit

temperature control parts. the liquid phase QCM biosensor makes Microchip MCU as core of circuit system

which can realize the stimulation of the quartz crystal and the detection of the frequency

the acquisition and control of the temperature and so on. Upper PC test results demonstrate that real temperature control precision is ± 0. 2 ℃ and the optimal resonant frequency can be detected smoothly

which prove that the system can reach the expected requirments well.

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Keywords

references

基于超高输入阻抗放大电路的生物传感器设计 [J]. 沙一峰. 传感器与微系统 . 2013(11)

基于金属有机框架化合物修饰的QCM湿度传感器 [J]. 郑倩,徐芬,孙立贤,焦成丽,张箭. 传感器与微系统 . 2013(03)

石英晶体微天平的新进展 [J]. 何建安,付龙,黄沫,卢煜东,吕贝尔,朱志强,方佳节,马宏伟. 中国科学:化学 . 2011(11)

基于无创血糖检测的传感器集成设计 [J]. 王弟亚,陈真诚,朱健铭,金星亮. 传感器与微系统 . 2009(12)

差分石英晶体微天平的设计与构造 [D]. 刘小伟. 中国科学技术大学 2009

On the measurement of thin liquid overlayers with the quartz-crystal microbalance [J] . Michael Rodahl,Bengt Kasemo. Sensors & Actuators: A. Physical . 1996 (1)

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