Fabrication of glass-PDMS film-glass sandwich microfluidic chip

WANG Li; LI Gang; JIN Qing-hui; ZHAO Jian-long

doi:10.13873/J.1000-9787(2016)01-0101-03

Chinese

您当前的位置：

首页 >

文章列表页 >

Fabrication of glass-PDMS film-glass sandwich microfluidic chip

更新时间：2025-09-11

- Fabrication of glass-PDMS film-glass sandwich microfluidic chip
- Vol. 35, Issue 1, Pages: 101-103(2016)
- 作者机构：
  
  1. 中国科学院上海微系统与信息技术研究所传感技术国家重点实验室
  2. 重庆大学光电工程学院
- 作者简介：
- 基金信息：
- DOI：10.13873/J.1000-9787(2016)01-0101-03
  CLC： TN492
- Published：2016
- 稿件说明：
移动端阅览
[1]王丽,李刚,金庆辉,赵建龙.玻璃-PDMS薄膜-玻璃夹心微流控芯片制作[J].传感器与微系统,2016,35(01):101-103.

WANG Li, LI Gang, JIN Qing-hui, et al. Fabrication of glass-PDMS film-glass sandwich microfluidic chip[J]. 2016, 35(1): 101-103.
[1]王丽,李刚,金庆辉,赵建龙.玻璃-PDMS薄膜-玻璃夹心微流控芯片制作[J].传感器与微系统,2016,35(01):101-103. DOI： 10.13873/J.1000-9787(2016)01-0101-03.

WANG Li, LI Gang, JIN Qing-hui, et al. Fabrication of glass-PDMS film-glass sandwich microfluidic chip[J]. 2016, 35(1): 101-103. DOI： 10.13873/J.1000-9787(2016)01-0101-03.

摘要

聚二甲基硅氧烷（PDMS）是目前微流控芯片中应用的最广泛的基质材料

但基于PDMS材料的微流控芯片在应用中存在溶剂易挥发、难以进行较长时间检测分析的问题。针对这些问题

发展了一种简便高效的"玻璃—PDMS薄膜—玻璃"（G—P—G）夹心式微流控芯片的制作方法。该方法巧妙利用聚酯（PET）胶片作为载体转移处理脆弱的结构化PDMS膜

然后通过等离子体处理将结构化PDMS膜夹在两个玻璃基板的中间

形成"玻璃—PDMS薄膜—玻璃"夹心结构芯片

由于玻璃材料的低通透性

使得芯片具有低溶剂挥发特性。该夹心式芯片的低溶剂挥发特性通过蛋白质结晶实验得到了验证。

Abstract

Polydimethylsiloxane（ PDMS） is currently the most widely used substrate material in microfluidic chip

but

microfluidic chip with this material has some problems in application

such as volatile solvent and difficulty in long term testing. To solve these problems

a simple and high-efficient fabrication method is developed to make‘glass-PDMS film-glass’（ G—P—G） sandwich structure microfluidic chip. This method uses polyester（ PET） film as carrier to transfer and handle structured PDMS film

and then the PDMS film is sandwiched between two glasses through the plasma treatment

to form sandwich structure chip

it has the feature of low solvent evaporation because of low permeability of glass material. Low solvent evaporation characteristics of the sandwich chip is validated through protein crystallization experiment.

关键词

Keywords

references

电化学传感器及其在芯片实验室中的应用 [J]. 刘长春,崔大付. 传感器技术 . 2003(07)

Investigation and improvement of reversible microfluidic devices based on glass–PDMS–glass sandwich configuration [J] . Qiang Chen,Gang Li,Yuan Nie,Shuhuai Yao,Jianlong Zhao. Microfluidics and Nanofluidics . 2014 (1-2)

Polymer microfluidic devices [J] . Holger Becker,Laurie E. Locascio. Talanta . 2002 (2)

Micro magnetic silicone elastomer membrane actuator [J] . Melvin Khoo,Chang Liu. Sensors & Actuators: A. Physical . 2001 (3)

Views

542

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A biosensor chip for CTC detection

Study on microsensor for monitoring of plant glucose in vivo

Research on microfluidic chip for sorting circulating tumor cells and its clinical application

Formation and culture of 3D cell spheroids based on microfluidic chip

Research on fibrinogen detection technology and experiment based on microfluidic chip

Related Author

FAN Xiao-yun

JIA Chun-ping

LI Gang

CONG Hui

MAO Guo-xin

JIN Qing-hui

YANG Lei

CHEN Da

Related Institution

Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences

The Affiliated Hospital of Nantong University

Beijing Research Center of Intelligent Equipment for Agriculture

College of Electronic and Information Engineering,Shandong University of Science and Technology

College of Life Sciences,Shanghai Normal University

⁰