Glucose continuous monitoring sensor based on hollow micro-needle array

LIU Shang; YUE Rui-feng

doi:10.13873/J.1000-9787(2015)01-0097-04

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Glucose continuous monitoring sensor based on hollow micro-needle array

更新时间：2025-09-11

- Glucose continuous monitoring sensor based on hollow micro-needle array
- Vol. 34, Issue 1, Pages: 97-100(2015)
- 作者机构：
  
  清华大学微电子学研究所
- 作者简介：
- 基金信息：
- DOI：10.13873/J.1000-9787(2015)01-0097-04
  CLC： TP212
- Published：2015
- 稿件说明：
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[1]刘尚,岳瑞峰.基于空心微针阵列的连续监测葡萄糖传感器[J].传感器与微系统,2015,34(01):97-100.

LIU Shang, YUE Rui-feng. Glucose continuous monitoring sensor based on hollow micro-needle array[J]. 2015, 34(1): 97-100.
[1]刘尚,岳瑞峰.基于空心微针阵列的连续监测葡萄糖传感器[J].传感器与微系统,2015,34(01):97-100. DOI： 10.13873/J.1000-9787(2015)01-0097-04.

LIU Shang, YUE Rui-feng. Glucose continuous monitoring sensor based on hollow micro-needle array[J]. 2015, 34(1): 97-100. DOI： 10.13873/J.1000-9787(2015)01-0097-04.

摘要

研制了一种基于空心微针阵列并可微痛刺入皮下实时连续监测人体血糖浓度的葡萄糖传感器。微针阵列由等间距的三根微针组成

分别作为工作电极、辅助电极和参比电极

其中工作电极与辅助电极采用表面溅射了Ti/Pt的空心不锈钢微针来制作

采用戊二醛—牛血清白蛋白交联法将葡萄糖氧化酶固定并仅置于作为工作电极的针尖通孔处;参比电极采用Ag/Ag Cl实心微针制作。测试结果表明:葡萄糖浓度在0

1 mmol·L-1范围内传感器输出电流为线性

灵敏度为0.575μA/（mmol·L-1）

响应时间为16 s

且具有很好的抗干扰性。

Abstract

A glucose sensor based on hollow micro-needle array is developed to pierce skin with slight pain and achieve continuous monitoring on human blood glucose concentration. The micro-needle array is constituted by three same spacing micro-needles

used as working electrode

auxiliary electrode and reference electrode of the biosensor

respectively

in which

working electrode and auxiliary electrode are both made of stainless hollow steel micro-needle with sputtered Ti / Pt films on the surface

use glutaraldehyde-BSA cross-linking method to fix glucose oxidase（ GOD） only on the tip of the micro-needle of working electrode; reference electrode is made of Ag / Ag Cl solid micro-needle. The test results show that the output current of the sensor is linear

in the range of 0

1 mmol·L- 1with glucose concentration

and the sensitivity is 0. 575 μA /（ mmol·L- 1）

and the response time is 16 s

and with good anti-jamming performance.

关键词

Keywords

references

皮下植入式葡萄糖传感器的研究进展 [J]. 沙宪政. 国外医学(生物医学工程分册) . 2003(01)

A miniaturized transcutaneous system for continuous glucose monitoring [J] . Robert A. Croce,SanthiSagar Vaddiraju,Jun Kondo,Yan Wang,Liang Zuo,Kai Zhu,Syed K. Islam,Diane J. Burgess,Fotios Papadimitrakopoulos,Faquir C. Jain. Biomedical Microdevices . 2013 (1)

Development of needle-type glucose sensor with high selectivity [J] . Qingling Yang,Plamen Atanasov,Ebtisam Wilkins. Sensors & Actuators: B. Chemical . 1998 (3)

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