Reasearch and fabrication of hybrid microfluidic dehydration chip

YONG Bei-bei; XU Guang-ming; ZHANG Hong

doi:10.13873/J.1000-9787(2014)11-0095-04

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Reasearch and fabrication of hybrid microfluidic dehydration chip

更新时间：2025-09-11

- Reasearch and fabrication of hybrid microfluidic dehydration chip
- Vol. 33, Issue 11, Pages: 95-98(2014)
- 作者机构：
  
  1. 浙江大学微分析系统研究所
  2. 浙江大学医学院第二附属医院
- 作者简介：
- 基金信息：
- DOI：10.13873/J.1000-9787(2014)11-0095-04
  CLC： TN492
- Published：2014
- 稿件说明：
移动端阅览
[1]雍蓓蓓,徐光明,张宏.复合式微流控脱水芯片的研制[J].传感器与微系统,2014,33(11):95-98.

YONG Bei-bei, XU Guang-ming, ZHANG Hong. Reasearch and fabrication of hybrid microfluidic dehydration chip[J]. 2014, 33(11): 95-98.
[1]雍蓓蓓,徐光明,张宏.复合式微流控脱水芯片的研制[J].传感器与微系统,2014,33(11):95-98. DOI： 10.13873/J.1000-9787(2014)11-0095-04.

YONG Bei-bei, XU Guang-ming, ZHANG Hong. Reasearch and fabrication of hybrid microfluidic dehydration chip[J]. 2014, 33(11): 95-98. DOI： 10.13873/J.1000-9787(2014)11-0095-04.

摘要

报道了一种复合式微流控脱水芯片。采用玻璃、聚二甲氧基硅氧烷（PDMS）和聚碳酸酯（PC）三种材质

采用不可逆封接方法分别制得玻璃—PDMS液路半芯片、PC—PDMS气路半芯片

中间夹一层聚四氟乙烯（PTFE）多孔滤膜

将两个半芯片可逆封接形成玻璃—PDMS…PDMS—PC结构的全芯片。该制备方法简单可靠

其液路半芯片和气路半芯片可以单独更换

使得使用成本降低。实验表明:该芯片脱水性能良好

可用于有机合成步骤中含水试剂的高效除水。

Abstract

A hybrid microfluidic dehydration chip is reported. The chip is made from glass

polydimethylsiloxane（ PDMS） and polycarbonate（ PC）

the fluid glass substrate and gas PC substrate are irreversibly bonded to an PDMS membrane to respectively form the fluid half chip and gas half chip

putting a layer of porous polytetrafluoroethylene（ PTFE） membrane filter between the two halves

then the gas and fluid halves are reversibly bonded to form a complete glass—PDMS … PDMS—PC chip. This fabrication method is simple and reliable

the fluid half and the gas half are allowed to be replaced individually

so the cost to use can be reduced.The experimental results show good dehydration performance and is expected to be used for efficient dehydration of water-bearing reagent in organic synthesis.

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references

高聚物微流控芯片上集成化气动微阀的研制 [J]. 黄山石,胡贤巧,何巧红,陈恒武. 传感器与微系统 . 2012(08)

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