AFM功能化成像与分子识别研究进展

徐小媛; 叶学松

doi:10.13873/j.1000-97872012.05.002

Chinese

您当前的位置：

首页 >

文章列表页 >

AFM功能化成像与分子识别研究进展

综述与评论 | 更新时间：2025-09-11

- AFM功能化成像与分子识别研究进展
- Research progress of AFM functionalized imaging and molecular recognition
- 传感器与微系统 2012年31卷第5期页码：1-3+7
- 作者机构：
  
  浙江大学生物医学工程系
- 作者简介：
- 基金信息：
  
  新世纪优秀人才支持计划资助项目（NCET—06—0527）;浙江省自然科学基金资助项目（Z1080300）
- DOI：10.13873/j.1000-97872012.05.002
  中图分类号： Q503
- 纸质出版：2012
- 稿件说明：
移动端阅览
[1]徐小媛,叶学松.AFM功能化成像与分子识别研究进展[J].传感器与微系统,2012,31(05):1-3+7.

XU Xiao-yuan, YE Xue-song. Research progress of AFM functionalized imaging and molecular recognition[J]. 2012, 31(5): 1-3+7.
[1]徐小媛,叶学松.AFM功能化成像与分子识别研究进展[J].传感器与微系统,2012,31(05):1-3+7. DOI： 10.13873/j.1000-97872012.05.002.

XU Xiao-yuan, YE Xue-song. Research progress of AFM functionalized imaging and molecular recognition[J]. 2012, 31(5): 1-3+7. DOI： 10.13873/j.1000-97872012.05.002.

摘要

在过去的几十年间

AFM在高分辨率分子成像与单分子检测上的应用得到了很大进展。AFM单分子力光谱学（SMFS）模式可以用于研究聚合物结构变化

生物信号传导过程的分子识别或蛋白折叠过程。提出了使用AFM进行功能化修饰和SMFS用于定位表面蛋白与多糖

研究表面蛋白的分子延展性的一些进展

并展望了研究前景与难点。

Abstract

In the past decades

AFM have great advances in high resolution molecular imaging and single molecule detection applications.AFM single molecular force spectroscopy（SMFS）are available to explore polymer structural changes

molecular identification of bio-signal transmission or protein folding process and unfolding process

the evidence of the relation between structural changes and functions is provided.Some progresses are mentioned such as using AFM in functionalization decoration

in locating using SMFS surface protein and polysaccharide and their elasticity.Prospects are also provided concerning future work and difficulties in AFM application.

关键词

Keywords

references

A competitive ELISA for the detection of group-specific antibody to equine encephalosis virus [J] . J.E. Crafford,A.J. Guthrie,M. Van Vuuren,P.P.C. Mertens,J.N. Burroughs,P.G. Howell,C.A. Batten,C. Hamblin. Journal of Virological Methods . 2011 (1)

Physical approaches for fabrication of organized nanostructure of resilin-mimetic elastic protein rec1-resilin [J] . Naba K. Dutta,Namita R. Choudhury,My Y. Truong,Misook Kim,Christopher M. Elvin,Anita J. Hill. Biomaterials . 2009 (28)

AFM phase imaging of soft-hydrated samples: A versatile tool to complete the chemical-physical study of liposomes [J] . Barbara Ruozi,Giovanni Tosi,Massimo Tonelli,Lucia Bondioli,Adele Mucci,Flavio Forni,Maria Angela Vandelli. Journal of Liposome Research . 2009 (1)

Effect of protein solution components in the adsorption of Herbaspirillum seropedicae GlnB protein on mica [J] . Cecília F.G. Ferreira,Elaine M. Benelli,Jorge J. Klein,Wido Schreiner,Paulo C. Camargo. Colloids and Surfaces B: Biointerfaces . 2009 (2)

Bovine red blood cell starvation age discrimination through a glutaraldehyde‐amplified dielectrophoretic approach with buffer selection and membrane cross‐linking [J] . ZacharyGagnon,JasonGordon,ShramikSengupta,Hsueh‐ChiaChang. ELECTROPHORESIS . 2008 (11)

Single-molecule studies of membrane proteins [J] . Daniel J Müller,K Tanuj Sapra,Simon Scheuring,Alexej Kedrov,Patrick L Frederix,Dimitrios Fotiadis,Andreas Engel. Current Opinion in Structural Biology . 2006 (4)

Synthesis of bilirubin imprinted polymer thin film for the continuous detection of bilirubin in an MIP/QCM/FIA system [J] . An-Hua Wu,Mei-Jywan Syu. Biosensors and Bioelectronics . 2006 (12)

浏览量

194

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

丝网印刷电极的电化学发光生物传感器