An intestinal bio-robot system which realizes noninvasive intestine examination and active actuation with enough energy supply is introduced.It consists of an in-vivo diagnostic module

a natural organism that serves as the locomotion mechanism

and an exterior control unit that actively drives and remotely controls the navigation and site-specific anchoring of the organism.Mud eel was chosen as the locomotion mechanism of the intestinal bio-robot.Based on its movement characteristics

a LabVIEW-programmed pulse generator was utilized to transmit electric stimulating signal to the surface neuronal microelectrodes on different parts of them in different environments.Experiments demonstrated that the mud eel could move forward by stimulating both the front and middle lateral lines of its trunk.Methods gained to control the locomotion of the intestinal bio-robot provide solid theoretical basis for its future prototype development.