genes and drugs have become increasingly important in terms of disease prevention
diagnostic and therapeutic applications.Aptamers are oligonucleotides(DNA or RNA) that can bind with high affinity and specificity to a wide range of target molecules
such as proteins
drugs
other organic and inorganic molecules.On the bases of the principle of electrochemical aptamer sensor
two kinds of electrochemical aptamer sensors are summarized
labeled and label free electrochemical aptamer sensor.The recent developments of these electrochemical aptamer sensors for the detection of protein
small organic molecule are addressed.
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references
核酸适体技术研究进展 [J]. 王成刚,莫志宏. 生物医学工程学杂志 . 2006(02)
Selection and analytical applications of aptamers [J] . Camille L.A. Hamula,Jeffrey W. Guthrie,Hongquan Zhang,Xing-Fang Li,X. Chris Le. Trends in Analytical Chemistry . 2006 (7)
Aptamers—basic research, drug development, and clinical applications [J] . Daniela Proske,Michael Blank,Raymund Buhmann,Ansgar Resch. Applied Microbiology and Biotechnology . 2005 (4)
Label-free bioelectronic detection of aptamer–protein interactions [J] . Abdel-Nasser Kawde,Marcela C. Rodriguez,Thomas M.H. Lee,Joseph Wang. Electrochemistry Communications . 2005 (5)
In vitro selection of nucleic acids for diagnostic applications [J] . Jay Hesselberth,Michael P Robertson,Sulay Jhaveri,Andrew D Ellington. Reviews in Molecular Biotechnology . 2000 (1)