A method is presented to compensate non-linearity and cold-side-offset for signal processing of thermocouple.A network model with two inputs and single output is constructed by radial basis function（RBF） neural network（NN）

which is trained by genetic algorithm.Under the NN model

non-linearity compensation and cold-side-offset adjustment of thermocouple are realized simultaneously.The simulation experimenls show that the testing error of this method is 0.095 %

it improves the accuracy in a wider range.