1. 重庆理工大学药学与生物工程学院
2. 重庆大学附属肿瘤医院
纸质出版:2025
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王春艳, 江怡娜, 李希望, 等. 基于微通道的肿瘤标志物磁性SERS传感器制备[J]. 传感器与微系统, 2025,(6):43-46+50.
王春艳, 江怡娜, 李希望, 等. 基于微通道的肿瘤标志物磁性SERS传感器制备[J]. 传感器与微系统, 2025,(6):43-46+50. DOI: 10.13873/J.1000-9787(2025)06-0043-04.
提出了一种在微通道内快速、低成本开展磁性表面增强拉曼散射(SERS)检测传感器的制备方法。外部磁力作用下,SERS探针之间、SERS探针与磁性捕获基底之间形成更多的SERS活性热点,对肝癌标志物甲胎蛋白(AFP)的定量检出限低至0.1 ng/mL
具有很好的检测灵敏度、重复性、选择性和良好的线性关系。与大体积的芯片外制备方法相比,微通道内磁性免疫传感器的制备可以节省试剂耗量、反应时间短、节约成本和时间,为SERS技术在肿瘤标志物检测领域的应用提供了良好的技术支撑。
金志明,徐林龙,张亚军,范一强.基于生物可降解微流控芯片的跨尺度注塑仿真[J].传感器与微系统,2023(03).
Jingshi Liu,Sai Xu,Liheng Sun,Songtao Hu,Jiao Sun,Min Liu,Cui Ma,Haipeng Liu,Ziqing Wang,Ying Yang,Biao Dong,Decheng Hong.Up-conversion fluorescence biosensor for sensitive detection of CA-125 tumor markers[J].Journal of Rare Earths,2019(09).
Meng Sifan,Chen Runzhi,Xie Jingxuan,Li Jing,Cheng Jiayi,Xu Yanan,Cao Haiting,Wu Xiaofeng,Zhang Qiang,Wang Houyu.Surface-enhanced Raman scattering holography chip for rapid, sensitive and multiplexed detection of human breast cancer-associated MicroRNAs in clinical samples[J].Biosensors and Bioelectronics,2021.
Gu Xuefang,Wang Kaiyue,Qiu Jiawei,Wang Yajie,Tian Shu,He Zhenkuan,Zong Ran,Kraatz Heinz-Bernhard.Enhanced electrochemical and SERS signals by self-assembled gold microelectrode arrays: A dual readout platform for multiplex immumoassay of tumor biomarkers[J].Sensors and Actuators: B. Chemical,2021.
Chunyan Wang,Xiaoqin Mu,Jia Huo,Bei Zhang,Kunyuan Zhang.Highly-efficient SERS detection for E. coli using a microfluidic chip with integrated NaYF 4 :Yb,Er@SiO 2 @Au under near-infrared laser excitation[J].Microsystem Technologies,2020.
Plasmon-Enhanced SERS Mapping Concentrated on a Single Bead for the Ultrasensitive and Multiplexed Immunoassay.[J].Analytical chemistry,2020.
İçöz Kutay,Akar Ünal,Ünal Ekrem.Microfluidic Chip based direct triple antibody immunoassay for monitoring patient comparative response to leukemia treatment.[J].Biomedical microdevices,2020.
Kurouski Dmitry,Dazzi Alexandre,Zenobi Renato,Centrone Andrea.Infrared and Raman chemical imaging and spectroscopy at the nanoscale.[J].Chemical Society reviews,2020.
Lin Shuang,Hasi Wuliji,Lin Xiang,Han Siqingaowa,Xiang Ting,Liang Shan,Wang Li.Lab-On-Capillary Platform for On-Site Quantitative SERS Analysis of Surface Contaminants Based on Au@4-MBA@Ag Core-Shell Nanorods.[J].ACS sensors,2020.
Arash Mohammadinejad,Reza Kazemi Oskuee,Reza Eivazzadeh-Keihan,Majid Rezayi,Behzad Baradaran,Ali Maleki,Mahmoud Hashemzaei,Ahad Mokhtarzadeh,Miguel de la Guardia.Development of biosensors for detection of alpha-fetoprotein: As a major biomarker for hepatocellular carcinoma[J].Trends in Analytical Chemistry,2020.
Hans D. Hallen,Brandon J. N. Long.Resonance Raman techniques for complex biological systems[J].Optical Engineering + Applications,2019.
Shuan Zhang,Chunyan Zhang,Yilei Jia,Xiaobo Zhang,Yunhui Dong,Xinjin Li,Qing Liu,Yueyun Li,Zengdian Zhao.Sandwich-type electrochemical immunosensor based on Au@Pt DNRs/NH 2 -MoSe 2 NSs nanocomposite as signal amplifiers for the sensitive detection of alpha-fetoprotein[J].Bioelectrochemistry,2019.
Hongjie Xiong,Jianhua Yan,Shundong Cai,Qunye He,Dongming Peng,Zhenbao Liu,Yanfei Liu.Cancer protein biomarker discovery based on nucleic acid aptamers[J].International Journal of Biological Macromolecules,2019.
Zhang Yuying,Mi Xue,Tan Xiaoyue,Xiang Rong.Recent Progress on Liquid Biopsy Analysis using Surface-Enhanced Raman Spectroscopy.[J].Theranostics,2019.
Yuanfeng Pang,Chaoguang Wang,LuChun Lu,Chongwen Wang,Zhiwei Sun,Rui Xiao.Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer[J].Biosensors and Bioelectronics,2019.
Reza Amin,Lu Li,Savas Tasoglu.Assessing reusability of microfluidic devices: Urinary protein uptake by PDMS-based channels after long-term cyclic use[J].Talanta,2018.
Nan-Fu Chiu,Shi-Yuan Fan,Cheng-Du Yang,Teng-Yi Huang.Carboxyl-functionalized graphene oxide composites as SPR biosensors with enhanced sensitivity for immunoaffinity detection[J].Biosensors and Bioelectronics,2017.
Chunyan Wang,Yi Xu,Conghui Deng,Zhixu Liu,Rong Wang,Huazhou Zhao.Design and preparation of a recyclable microfluidic SERS chip with integrated Au@Ag/TiO2 NTs[J].RSC Advances,2016.
Wang Chongwen,Wang Junfeng,Li Min,Qu Xinyan,Zhang Kehan,Rong Zhen,Xiao Rui,Wang Shengqi.A rapid SERS method for label-free bacteria detection using polyethylenimine-modified Au-coated magnetic microspheres and Au@Ag nanoparticles.[J].The Analyst,2016.
Chunyan Wang,Yi Xu,Huazhou Zhao,Chen Gang,Chunhong Lai,Xin Liao,Rong Wang.Detection and analysis of SERS effect of nano gold by self-assembly chemical plating composite method[J].Applied Surface Science,2015.
Ni J,Lipert R J,Dawson G B,Porter M D.Immunoassay readout method using extrinsic Raman labels adsorbed on immunogold colloids.[J].Analytical chemistry,1999(21).
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