1. 成都中医药大学智能医学学院
2. 中国科学院上海微系统与信息技术研究所传感技术国家重点实验室
纸质出版:2025
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曾睿, 李明强, 赵斌, 等. 电子鼻在疾病呼气诊断中的最新研究进展[J]. 传感器与微系统, 2025,(4):1-7.
曾睿, 李明强, 赵斌, 等. 电子鼻在疾病呼气诊断中的最新研究进展[J]. 传感器与微系统, 2025,(4):1-7. DOI: 10.13873/J.1000-9787(2025)04-0001-07.
电子鼻(eNose)可用于呼出气体中的挥发性有机化合物(VOCs)检测,由于其具有非侵入性、快速检测等优势,近年来在疾病诊断中展现出巨大潜力。本文综述了近5年电子鼻在气体传感器阵列、信号采集与处理以及模式识别等关键技术的研究现状,系统回顾了其在呼吸系统疾病、消化系统疾病、糖尿病以及多种癌症等疾病中的应用。随着技术的不断进步,电子鼻已开始在疾病早期筛查和诊断中发挥越来越重要的作用。尽管当前仍面临传感器长期稳定性和大规模临床验证等挑战,但随着微纳传感技术和人工智能(AI)算法的迅速发展,电子鼻有望在疾病呼气诊断中得到更广泛的应用。
徐昊,章检明,王中鹏,张丽娟,迟梁,何成.基于电子鼻的深度卷积神经网络茯苓产地分类方法[J].传感器与微系统,2023(12).
刘旭,余隽,李中洲,魏广芬,黄正兴,朱慧超.用于苹果品质监测的多温度扫描电子鼻系统[J].传感器与微系统,2023(10).
王乐,李龙,段秋阳,李华曜,刘欢.高精度电子鼻采样电路设计与检测系统开发[J].仪表技术与传感器,2023(09).
陶洋,黎春燕,梁志芳,杨皓诚.基于对抗学习的电子鼻传感器漂移补偿算法[J].传感器与微系统,2022(06).
Nik Dennler,Damien Drix,Tom P A Warner,Shavika Rastogi,Cecilia Della Casa,Tobias Ackels,Andreas T Schaefer,André van Schaik,Michael Schmuker.High-speed odor sensing using miniaturized electronic nose.[J].Science advances,2024.
Wangze Ni,Tao Wang,Yu Wu,Xue Liu,Zhuoheng Li,Rui Yang,Kai Zhang,Jianhua Yang,Min Zeng,Nantao Hu,Bin Li,Zhi Yang.Multi-task deep learning model for quantitative volatile organic compounds analysis by feature fusion of electronic nose sensing[J].Sensors and Actuators: B. Chemical,2024.
Ivonne J. H. Schoenaker,Alexander Pennings,Henderik L. van Westreenen,Evelyn J. Finnema,Richard M. Brohet,Julia Hanevelt,Wouter H. de Vos Tot Nederveen Cappel,Jarno Melenhorst.Is an Electronic Nose Able to Predict Clinical Response following Neoadjuvant Treatment of Rectal Cancer? A Prospective Pilot Study[J].Journal of Clinical Medicine,2024.
Xuemei Liu,Qiaofen Chen,Shiyuan Xu,Jiaying Wu,Jingwen Zhao,Zhengfu He,Aiwu Pan,Jianmin Wu.A Prototype of Graphene E-Nose for Exhaled Breath Detection and Label-Free Diagnosis of Helicobacter Pylori Infection.[J].Advanced science (Weinheim, Baden-Wurttemberg, Germany),2024.
Richard E Evenhuis,Ibtissam Acem,Veroniek M van Praag,Robert Jp van der Wal,Michael Pa Bus,Michiel Aj van de Sande.Diagnosis of chondrosarcoma in a noninvasive way using volatile organic compounds in exhaled breath: a pilot study.[J].Future oncology (London, England),2024.
Jiaying Wu,Shiyuan Xu,Xuemei Liu,Jingwen Zhao,Zhengfu He,Aiwu Pan,Jianmin Wu.High-precision Helicobacter pylori infection diagnosis using a dual-element multimodal gas sensor array.[J].The Analyst,2024.
Gaetano Rocco,Giorgio Pennazza,Kay See Tan,Stijn Vanstraelen,Marco Santonico,Robert J Corba,Bernard J Park,Smita Sihag,Matthew J Bott,Pierfilippo Crucitti,James M Isbell,Michelle S Ginsberg,Hallie Weiss,Raffaele Antonelli Incalzi,Panaiotis Finamore,Filippo Longo,Alessandro Zompanti,Simone Grasso,Stephen B Solomon,Alain Vincent,Alexa McKnight,Michael Cirelli,Carmela Voli,Susan Kelly,Mario Merone,Daniela Molena,Katherine Gray,James Huang,Valerie W Rusch,Manjit S Bains,Robert J Downey,Prasad S Adusumilli,David R Jones.A real-world assessment of stage I lung cancer through electronic nose technology.[J].Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,2024.
Anh Tuan Trong Tran,Kamrul Hassan,Tran Thanh Tung,Ashis Tripathy,Ashok Mondal,Dusan Losic.Graphene and metal-organic framework hybrids for high-performance sensors for lung cancer biomarker detection supported by machine learning augmentation.[J].Nanoscale,2024.
Gaidamavichute Viktoria,Knyazeva Marina,Khozina Elena,Men’shchikov Ilya,Safaev Ruslan,Shkolin Andrey.A LA-BTC MOF as a sensor element of an electronic nose for selective adsorption of biomarkers of diseases: Molecular dynamics simulations of adsorption[J].Materials Today Communications,2024.
Alberto Gudiño Ochoa,Julio Alberto García Rodríguez,Raquel Ochoa Ornelas,Jorge Ivan Cuevas Chávez,Daniel Alejandro Sánchez Arias.Noninvasive Diabetes Detection through Human Breath Using TinyML-Powered E-Nose[J].Sensors,2024.
Wonseok Ku,Geonhee Lee,Ju Yeon Lee,Do Hyeong Kim,Ki Hong Park,Jongtae Lim,Donghwi Cho,Seung Chul Ha,Byung Gil Jung,Heesu Hwang,Wooseop Lee,Huisu Shin,Ha Seon Jang,Jeong O Lee,Jin Ha Hwang.Rational design of hybrid sensor arrays combined synergistically with machine learning for rapid response to a hazardous gas leak environment in chemical plants.[J].Journal of hazardous materials,2024.
Khokhar Manoj.Non-invasive detection of renal disease biomarkers through breath analysis.[J].Journal of breath research,2024.
Jang Woong Bi,Yi Dongwon,Nguyen Thanh Mien,Lee Yujin,Lee Eun Ji,Choi Jaewoo,Kim You Hwan,Choi EunJung,Oh JinWoo,Kwon SangMo.Artificial Neural Processing-Driven Bioelectronic Nose for The Diagnosis of Diabetes And Its Complications.[J].Advanced healthcare materials,2023.
Moura Pedro Catalão,Raposo Maria,Vassilenko Valentina.Breath Volatile Organic Compounds (VOCs) as Biomarkers for the Diagnosis of Pathological Conditions: A Review.[J].Biomedical journal,2023.
Shang Guojun,Dinh Dong,Mercer Tara,Yan Shan,Wang Shan,Malaei Behnaz,Luo Jin,Lu Susan,Zhong ChuanJian.Chemiresistive Sensor Array with Nanostructured Interfaces for Detection of Human Breaths with Simulated Lung Cancer Breath VOCs.[J].ACS sensors,2023.
Kort Sharina,BrusseKeizer Marjolein,Schouwink Dr Hugo,Citgez Emanuel,de Jongh Frans,van Putten John,van den Borne Ben,Kastelijn Lisanne,Stolz Daiana,Schuurbiers Milou,van den Heuvel Michel,van Geffen Wouter H,van der Palen Job.Diagnosing non-small cell lung cancer by exhaled-breath profiling using an electronic nose: a multicentre validation study.[J].Chest,2022.
Kwiatkowski Andrzej,Borys Sebastian,Sikorska Katarzyna,Drozdowska Katarzyna,Smulko Janusz M..Clinical studies of detecting COVID-19 from exhaled breath with electronic nose[J].Scientific Reports,2022.
Tang Wenying,Chen Zhesi,Song Zhilong,Wang Chen,Wan Zhu'an,Chan Chak Lam Jonathan,Chen Zhuo,Ye Wenhao,Fan Zhiyong.Microheater Integrated Nanotube Array Gas Sensor for Parts-Per-Trillion Level Gas Detection and Single Sensor-Based Gas Discrimination.[J].ACS nano,2022.
Kang Mingu,Cho Incheol,Park Jaeho,Jeong Jaeseok,Lee Kichul,Lee Byeongju,Del Orbe Henriquez Dionisio,Yoon Kukjin,Park Inkyu.High Accuracy Real-Time Multi-Gas Identification by a Batch-Uniform Gas Sensor Array and Deep Learning Algorithm.[J].ACS sensors,2022.
Day Brian A,Wilmer Christopher E.Computational Design of MOF-Based Electronic Noses for Dilute Gas Species Detection: Application to Kidney Disease Detection.[J].ACS sensors,2021.
Zaim Omar,Diouf Alassane,El Bari Nezha,Lagdali Naoual,Benelbarhdadi Imane,Ajana Fatima Zohra,Llobet Eduard,Bouchikhi Benachir.Comparative analysis of volatile organic compounds of breath and urine for distinguishing patients with liver cirrhosis from healthy controls by using electronic nose and voltammetric electronic tongue[J].Analytica Chimica Acta,2021.
Li Dongsheng,Shao Yuzhou,Zhang Qian,Qu Mengjiao,Ping Jianfeng,Fu YongQing,Xie Jin.A flexible virtual sensor array based on laser-induced graphene and MXene for detecting volatile organic compounds in human breath.[J].The Analyst,2021.
Paleczek Anna,Grochala Dominik,Rydosz Artur.Artificial Breath Classification Using XGBoost Algorithm for Diabetes Detection[J].Sensors,2021.
Lammers Ariana,Brinkman Paul,Te Nijenhuis Louwrina H,de Vries Rianne,Dagelet Yennece W F,Duijvelaar Erik,Xu Binbin,AbdelAziz Mahmoud I,Vijverberg Susanne J,Neerincx Anne H,Frey Urs,Lutter Rene,Maitlandvan der Zee Anke H,Sterk Peter J,Sinha Anirban.Increased day-to-day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma.[J].Allergy,2021.
Juan C. Rodriguez Gamboa,Adenilton J. da Silva,Ismael C. S. Araujo,Eva Susana Albarracin E.,Cristhian M. Duran A..Validation of the rapid detection approach for enhancing the electronic nose systems performance, using different deep learning models and support vector machines[J].Sensors and Actuators: B. Chemical,2021.
Ramji Kalidoss,Kalidoss Ramji,Umapathy Snekhalatha,Kothalam Radhakrishnan,Sakthivelu Uthvag.Adsorption kinetics feature extraction from breathprint obtained by graphene based sensors for diabetes diagnosis[J].Journal of Breath Research,2021.
Ettema Rozemarijn,Lenders Mathieu,Vliegen Jos,Slettenaar Astrid,TjepkemaCloostermans Marleen C,de Vos Cecile.Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study.[J].Journal of breath research,2020.
Raspagliesi Francesco,Bogani Giorgio,Benedetti Simona,Grassi Silvia,Ferla Stefano,Buratti Susanna.Detection of Ovarian Cancer through Exhaled Breath by Electronic Nose: A Prospective Study[J].Cancers,2020.
Lorena Díaz de León Martínez,Maribel Rodriguez Aguilar,Patricia Gorocica Rosete,Carlos Alberto Domínguez Reyes,Verónica Martínez Bustos,Juan Alberto Tenorio Torres,Omar Ornelas Rebolledo,José Alfonso Cruz Ramos,Berenice Balderas Segura,Rogelio Flores Ramírez.Identification of profiles of volatile organic compounds in exhaled breath by means of an electronic nose as a proposal for a screening method for breast cancer: a case-control study.[J].Journal of Breath Research,2020.
Peters Yonne,Schrauwen Ruud W M,Tan Adriaan C,Bogers Sanne K,de Jong Bart,Siersema Peter D.Detection of Barrett's oesophagus through exhaled breath using an electronic nose device.[J].Gut,2020.
van de Goor Rens M G E,van Hooren Michel R A,Henatsch Darius,Kremer Bernd,Kross Kenneth W.Detecting head and neck squamous carcinoma using a portable handheld electronic nose.[J].Head & neck,2020.
van Dartel Dieuwke,Schelhaas H Jurgen,Colon Albert J,Kho Kuan H,de Vos Cecile C.Breath analysis in detecting epilepsy.[J].Journal of breath research,2020.
Maribel Rodríguez-Aguilar,Lorena Díaz de León-Martínez,Patricia Gorocica-Rosete,Rogelio Pérez Padilla,Ireri Thirión-Romero,Omar Ornelas-Rebolledo,Rogelio Flores-Ramírez.Identification of breath-prints for the COPD detection associated with smoking and household air pollution by electronic nose[J].Respiratory Medicine,2020.
Chen Qiaofen,Chen Zhao,Liu Dong,He Zhengfu,Wu Jianmin.Constructing E-Nose Using Metal-Ion Induced Assembly of Graphene Oxide for Diagnosis of Lung Cancer via Exhaled Breath.[J].ACS applied materials & interfaces,2020.
Chen Chung-Yu,Lin Wei-Chi,Yang Hsiao-Yu.Diagnosis of ventilator-associated pneumonia using electronic nose sensor array signals: solutions to improve the application of machine learning in respiratory research.[J].Respiratory research,2020(1).
Liu Huixiang,Li Qing,Gu Yu.A multi-task learning framework for gas detection and concentration estimation[J].Neurocomputing,2020.
Ye Huixian,Shi Chen,Li Jiang,Tian Li,Zeng Min,Wang Hui,Li Qiliang.New Alternating Current Noise Analytics Enables High Discrimination in Gas Sensing.[J].Analytical chemistry,2020.
Mahmoud I. Abdel-Aziz,Paul Brinkman,Susanne J.H. Vijverberg,Anne H. Neerincx,Rianne de Vries,Yennece W.F. Dagelet,John H. Riley,Simone Hashimoto,Kian Fan Chung,Ratko Djukanovic,Louise J. Fleming,Clare S. Murray,Urs Frey,Andrew Bush,Florian Singer,Gunilla Hedlin,Graham Roberts,Sven-Erik Dahlén,Ian M. Adcock,Stephen J. Fowler,Karen Knipping,Peter J. Sterk,Aletta D. Kraneveld,Anke H. Maitland-van der Zee.eNose breath prints as a surrogate biomarker for classifying patients with asthma by atopy[J].The Journal of Allergy and Clinical Immunology,2020.
van Keulen Kelly E,Jansen Maud E,Schrauwen Ruud W M,Kolkman Jeroen J,Siersema Peter D.Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer.[J].Alimentary pharmacology & therapeutics,2019.
Danila Germanese,Sara Colantonio,Mario D’Acunto,Veronica Romagnoli,Antonio Salvati,Maurizia Brunetto.An E-Nose for the Monitoring of Severe Liver Impairment: A Preliminary Study[J].Sensors,2019.
Antonia M I Saktiawati,Ymkje Stienstra,Yanri W Subronto,Ning Rintiswati,Sumardi,Jan-Willem Gerritsen,Henny Oord,Onno W Akkerman,Tjip S van der Werf.Sensitivity and specificity of an electronic nose in diagnosing pulmonary tuberculosis among patients with suspected tuberculosis.[J].PLoS ONE,2019.
Akira Tiele,Alfian Wicaksono,Jiten Kansara,Ramesh P. Arasaradnam,James A. Covington.Breath Analysis Using eNose and Ion Mobility Technology to Diagnose Inflammatory Bowel Disease—A Pilot Study[J].Biosensors,2019.
Gardner Julian W..Detection of vapours and odours from a multisensor array using pattern recognition Part 1. Principal component and cluster analysis[J].Sensors and Actuators B: Chemical,1991(1-2).
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