天津大学精密仪器与光电子工程学院
纸质出版:2025
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祝可伊, 薛茜男. 基于磷脂双层的纳米粒子微传感分析系统[J]. 传感器与微系统, 2025,(2):62-66.
祝可伊, 薛茜男. 基于磷脂双层的纳米粒子微传感分析系统[J]. 传感器与微系统, 2025,(2):62-66. DOI: 10.13873/J.1000-9787(2025)02-0062-05.
大气污染日益严重,悬浮纳米粒子和病毒颗粒通过肺泡进入体内,给人体带来未知的健康危害。本文通过将磷脂双层集成在场效应晶体管延长栅极表面体外模拟局部肺泡膜,设计并搭建了肺泡膜—纳米粒子相互作用实时监测系统。通过对粒子作用下源漏电流尖峰信号的检测与分析,该系统可以获取纳米粒子/病毒颗粒与肺泡膜相互作用行为的精确定量数据。测试结果表明,所提出微传感系统表面磷脂膜具有良好的完整性和生物活性,集成磷脂双层的延长栅极性能稳定、响应快、灵敏度高,可以准确、及时捕获带电离子跨膜转移信号,有望成为膜—粒相互作用行为有效的体外研究平台,推广用于广泛评估纳米粒子对人体健康的影响。
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Department of Mechanical Engineering , University of Connecticut , Storrs , Connecticut 06269 , United States.,Department of Mechanical Engineering , University of Connecticut , Storrs , Connecticut 06269 , United States.,Department of Mechanics and Engineering Science, College of Engineering, and Beijing Innovation Center for Engineering Science and Advanced Technology , Peking University , Beijing 100871 , China.,Department of Mechanical Engineering and Institute of Materials Science , University of Connecticut , Storrs , Connecticut 06269 , United States..Membrane Wrapping Efficiency of Elastic Nanoparticles during Endocytosis: Size and Shape Matter.[J].ACS nano,2019.
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Dong-Sun Kim,Jee-Eun Park,Jang-Kyoo Shin,Pan Kyeom Kim,Geunbae Lim,Shuichi Shoji.An extended gate FET-based biosensor integrated with a Si microfluidic channel for detection of protein complexes[J].Sensors & Actuators: B. Chemical,2006.
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