1. 南通大学机械工程学院
2. 南通大学生命科学学院
纸质出版:2024
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耿迁迁, 张华丽, 孙利军. 用于粒子捕获的单列环状微流控芯片[J]. 传感器与微系统, 2024,(7):110-113.
耿迁迁, 张华丽, 孙利军. 用于粒子捕获的单列环状微流控芯片[J]. 传感器与微系统, 2024,(7):110-113. DOI: 10.13873/J.1000-9787(2024)07-0110-04.
单细胞分析在生物医学研究和临床医学中具有重要意义,微流控芯片是实现单细胞分析的有效工具。为了实现单个细胞的高效捕获与实时观测,基于流体力学设计了一种单列环状微流控芯片。对捕获腔设计了4种不同尺寸(15
20
25
30μm)的后端通道。采用Fluent软件对单列环状微流控芯片进行速度流场分析。模拟结果表明:后端通道为15μm和20μm的微流控芯片粒子捕获效果最好。选用后端通道为20μm尺寸的微流控芯片,进行单个聚苯乙烯微粒的捕获实验,实验结果表明:单列环状微流控芯片的捕获粒子效率可达到91.67%
为后续细胞捕获与细胞培养提供了研究基础。
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Wenshuai Wu,Fengtian Wu,Shan Zhang,Xiong Ding,Tao Zhang,Ying Yang,Ying Mu.A self-powered bidirectional partition microfluidic chip with embedded microwells for highly sensitive detection of EGFR mutations in plasma of non-small cell lung cancer patients[J].Talanta,2020.
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