1. 大连理工大学机械工程学院
2. 大连理工大学辽宁省微纳米技术及系统重点实验室
纸质出版:2024
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左少华, 丁来钱, 李扬, 等. 基于薄膜壳体理论的仿淋巴瓣膜结构设计[J]. 传感器与微系统, 2024,(2):72-75.
左少华, 丁来钱, 李扬, 等. 基于薄膜壳体理论的仿淋巴瓣膜结构设计[J]. 传感器与微系统, 2024,(2):72-75. DOI: 10.13873/J.1000-9787(2024)02-0072-04.
淋巴系统中的瓣膜结构是控制淋巴液单向流动的关键结构,进而影响肿瘤细胞的淋巴转移过程。基于薄膜壳体理论设计了仿淋巴瓣膜结构,通过COMSOL有限元仿真分析了瓣膜厚度、弹性对其变形的影响。配制了聚二甲基硅氧烷(PDMS)与Ecoflex00—30的混合材料,通过调整二者的体积比,使其杨氏模量与生物组织实际值更接近。采用软刻蚀技术制作了仿淋巴管微通道,测试了其单向截流性能。结果表明:在80 Pa压力下,仿淋巴瓣膜结构无明显漏液现象,单向截流性能良好。
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