北京化工大学机电工程学院
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方以勒, 杜唯佳, 林龙, 等. 微针葡萄糖传感器的制备与性能研究[J]. 传感器与微系统, 2023,(1):75-78.
方以勒, 杜唯佳, 林龙, 等. 微针葡萄糖传感器的制备与性能研究[J]. 传感器与微系统, 2023,(1):75-78. DOI: 10.13873/J.1000-9787(2023)01-0075-04.
针对目前糖尿病血糖监测通常需要采集指血,耐受性差且监测数据不连续的问题,迫切需要开发一种无疼痛持续监测血糖水平的装置,提出了一种基于微针(MN)的电流酶基葡萄糖连续监测传感器,主要是在MN表面修饰银(Ag)层与包覆葡萄糖氧化酶(GOx)的导电高分子聚3
4—乙烯二氧噻吩(PEDOT)层来实现葡萄糖信号检测。聚乳酸MN阵列由7×7的圆锥形MN组成,MN高度和底径分别为550μm和250μm
同时,探究了熔融热压法制备MN阵列、微电子打印机喷涂Ag墨、电沉积法制备包覆GOx的PEDOT层的工艺。实验结果表明:修饰后的MN电极在生理相关范围内具有良好的线性响应(0~35 mmol/L)和响应时间(9 s)
为MN无创连续监测人体生理指标的实际应用提供一定技术基础。
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