纤维材料改性国家重点实验室东华大学材料科学与工程学院 2. 济南金泉生物科技有限公司
纸质出版:2022
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敬灵芝, 范苏娜, 姚响, 等. 基于微流控芯片构建复合力学刺激细胞反应器[J]. 传感器与微系统, 2022,(8):6-10.
基于微流控芯片构建复合力学刺激细胞反应器[J]. 2022, (8): 6-10.
敬灵芝, 范苏娜, 姚响, 等. 基于微流控芯片构建复合力学刺激细胞反应器[J]. 传感器与微系统, 2022,(8):6-10. DOI: 10.13873/J.1000-9787(2022)08-0006-05.
基于微流控芯片构建复合力学刺激细胞反应器[J]. 2022, (8): 6-10. DOI: 10.13873/J.1000-9787(2022)08-0006-05.
基于软光刻技术制备了微流控芯片,开发了芯片基材表面修饰技术,有效促进了细胞在微通道内表面的黏附生长,为细胞灌流培养奠定了基础。进一步结合可控的灌流系统和往复伸缩机,构建了对细胞培养体系可同时施加流体剪切力和压力的复合力学刺激细胞反应器。通过在微通道中置入光纤光栅传感器,还可使该反应器能实时监测通道中的压力。该反应器简便小巧,可置于细胞培养箱中,用于研究流体剪切力—压力复合力学刺激对细胞行为的影响。其在复合力学刺激培养细胞或微组织相关研究领域具有潜在的应用价值。
基于软光刻技术制备了微流控芯片,开发了芯片基材表面修饰技术,有效促进了细胞在微通道内表面的黏附生长,为细胞灌流培养奠定了基础。进一步结合可控的灌流系统和往复伸缩机,构建了对细胞培养体系可同时施加流体剪切力和压力的复合力学刺激细胞反应器。通过在微通道中置入光纤光栅传感器,还可使该反应器能实时监测通道中的压力。该反应器简便小巧,可置于细胞培养箱中,用于研究流体剪切力—压力复合力学刺激对细胞行为的影响。其在复合力学刺激培养细胞或微组织相关研究领域具有潜在的应用价值。
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