1. 贵州大学大数据与信息工程学院
2. 贵州大学贵州省光电子技术及应用重点实验室
3. 贵州大学医学院
纸质出版:2021
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聂倩, 张青青, 白忠臣, 等. 基于银岛薄膜SERS基底的Tau蛋白生物传感器[J]. 传感器与微系统, 2021,(11):17-20+24.
聂倩, 张青青, 白忠臣, 等. 基于银岛薄膜SERS基底的Tau蛋白生物传感器[J]. 传感器与微系统, 2021,(11):17-20+24. DOI: 10.13873/J.1000-9787(2021)11-0017-04.
本文制备了银岛薄膜基底
并利用表面增强拉曼散射(SERS)效应构建了检测Tau蛋白的生物传感器。采用旋涂法制备聚醋酸乙烯醇(PVA)/AgNO
3
复合薄膜;然后
通过热还原法制备了具有银岛结构薄膜的SERS基底。使用三聚氰胺作为探针分子
结果表明:基底的SERS增强因子可以达到1 149;此外
利用SERS基底检测Tau蛋白
其检测限可达为1 mg/L;且在10~100 mg/L范围内
Tau蛋白浓度与拉曼强度具有线性的"量—效"关系。由于传感器的良好稳定性和低廉加工成本
在阿尔茨海默氏病的早期筛查和诊断等方面具有较好的应用潜力。
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