By using MATLAB software

mask pattern of quadruplets-microneedle is designed

and the mask pattern of quadruplets-microneedle is improved by simulation and mask pattern compensation method

so that the strength of the prepared quadruplets-microneedle is increased. PMMA quadruplets-microneedle is prepared by moving X-ray exposure technology twice. By using the capillary phenomenon

the quadruplets-microneedle array can extract the aniline blue solution

because the viscosity of the liquid is similar to that of blood

which proves that the microneedle array can be used for blood extraction. The strength test is carried out by inserting the micro needle into the polyurethane film and testing the applied load. It is verified that the prepared micro-needle array has sufficient strength and the load onto the microneedle is 0. 4 N/needle.