A noninvasive skin impedance measurement system is designed based on AD5933 to evaluate skin permeability

improve efficiency of transdermal delivery and extraction of target-tissue fluid. Low frequency skin impedance is measured based on the two-electrode proportional method and take advantage of software calibration and compensation

clock frequency switching and range automatic switching. Impedance measurement before and after treatment is verified by experiment based on electroporation method for penetration. It is shown by the experimental results that the system can be used to characterize the permeability of the skin and provide basis for the adjustment of wearable device parameters related to human physiology and biochemistry detection.