无线光刺激与神经传感系统

袁明军; 岳森; 张云鹏; 赵晓东; 王守岩

doi:10.13873/J.1000-9787(2016)06-0062-04

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无线光刺激与神经传感系统

设计与制造 | 更新时间：2025-09-11

- 无线光刺激与神经传感系统
- Wireless neural sensing system integrated optical stimulation
- 传感器与微系统 2016年35卷第6期页码：62-65
- 作者机构：
  
  1. 中国科学院苏州生物医学工程技术研究所
  2. 中国科学院长春光学精密机械与物理研究所
  3. 中国科学院大学
- 作者简介：
- 基金信息：
  
  国家自然科学基金面上资助项目（81471745）
- DOI：10.13873/J.1000-9787(2016)06-0062-04
  中图分类号： R318.6
- 纸质出版：2016
- 稿件说明：
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[1]袁明军,岳森,张云鹏,赵晓东,王守岩.无线光刺激与神经传感系统[J].传感器与微系统,2016,35(06):62-65.

YUAN Ming-jun, YUE Sen, ZHANG Yun-peng, et al. Wireless neural sensing system integrated optical stimulation[J]. 2016, 35(6): 62-65.
[1]袁明军,岳森,张云鹏,赵晓东,王守岩.无线光刺激与神经传感系统[J].传感器与微系统,2016,35(06):62-65. DOI： 10.13873/J.1000-9787(2016)06-0062-04.

YUAN Ming-jun, YUE Sen, ZHANG Yun-peng, et al. Wireless neural sensing system integrated optical stimulation[J]. 2016, 35(6): 62-65. DOI： 10.13873/J.1000-9787(2016)06-0062-04.

摘要

光遗传神经调控正在向闭环技术发展

针对实验动物可自由活动的需求

研发具有大范围光刺激、神经信号同步记录、无线程控等功能的无线光刺激与神经传感系统。该系统包括光刺激—电记录神经接口、刺激传感模块、无线收发模块以及上位机软件。可无线实时调节光刺激频率、幅度和占空比等参数

并同步采集神经信号。给予小鼠刺激运动皮层30Hz光刺激

小鼠运动明显增强

同时记录到刺激诱发的脑电信号。系统为光遗传技术提供多功能神经调控平台

有助于神经环路和神经疾病的长时程研究。

Abstract

Neuromodulation based on optogenetics is developed toward closed-loop control

a wireless light stimulation and neural sensing system is developed for requirements of free moving of test animal which has functions of larger range of optical stimulation

synchronous record

wireless programmable

which contains light stimulation-electric record neural interface

a stimulating and sensing module

a wireless transceiver module and upper PC software. The device can adjust light stimulation frequency

amplitude

duty ratio wirelessly and in realtime and synchronously acquire neural signal. The animal experiment shows that 30 Hz light stimulation at motor cortex movement of the mice is obviously enhanced

and EEG signal provoked by stimulation is recorded simultaneously. The system provides a multifunction neural regulation platform for optogenetics

which is beneficial to long schedule research for neural circuit and neural disease.

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references

Closed-Loop and Activity-Guided Optogenetic Control [J] . Logan Grosenick,James H. Marshel,Karl Deisseroth. Neuron . 2015 (1)

Optical Neural Interfaces [J] . Melissa R. Warden,Jessica A. Cardin,Karl Deisseroth. Annual Review of Biomedical Engineering . 2014

Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications [J] . Jing Wang,Fabien Wagner,David A Borton,Jiayi Zhang,Ilker Ozden,Rebecca D Burwell,Arto V Nurmikko,Rick van Wagenen,Ilka Diester,Karl Deisseroth. Journal of Neural Engineering . 2012 (1)

A wirelessly powered and controlled device for optical neural control of freely-behaving animals [J] . Christian T Wentz,Jacob G Bernstein,Patrick Monahan,Alexander Guerra,Alex Rodriguez,Edward S Boyden. Journal of Neural Engineering . 2011 (4)

The Development and Application of Optogenetics [J] . Lief Fenno,Ofer Yizhar,Karl Deisseroth. Annual Review of Neuroscience . 2011

Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue [J] . Jiayi Zhang,Farah Laiwalla,Jennifer A Kim,Hayato Urabe,Rick Van Wagenen,Yoon-Kyu Song,Barry W Connors,Feng Zhang,Karl Deisseroth,Arto V Nurmikko. Journal of Neural Engineering . 2009 (5)

DEEP BRAIN STIMULATION [J] . Joel S. Perlmutter,Jonathan W. Mink. Annual Review of Neuroscience . 2006

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