YANG Han-lin, CHEN Da, LIU Yi-jian, et al. Fabrication of immune globulin sensor based on film bulk acoustic resonator[J]. 2015, 34(8): 80-82. DOI: 10.13873/J.1000-9787(2015)08-0080-03.
基于薄膜体声波谐振器的免疫球蛋白传感器制备
摘要
研制了一种基于薄膜体声波谐振器(FBAR)的生物免疫球蛋白传感器
该FBAR采用Al N作为压电层
3对Ti/W金属层作为布拉格声学反射层
工作频率为2.047 GHz
回波损耗为-32 d B。利用自组装膜法修饰顶部金电极敏感区域。测试了免疫球蛋白G抗体和抗原的特异性结合前后传感器的指标变化。结果得到传感器的Q值和灵敏度分别达到846
3.38 k Hz·cm2/ng
远高于广泛使用的石英晶体微天平(QCM)
具有广阔的应用前景。
Abstract
An immune globulin( IG) sensor based on thin film bulk acoustic resonator( FBAR) is presented
which works at 2. 047 GHz with- 32 d B return loss
consisting of an Al N piezoelectric stack and three pairs of Ti / W Bragg reflector. Self-assembled monolayers( SAMs) are applied to modify the top Au electrode sensitive area. Index changes of sensor before and after combination of antigen and antibody of IG are test. The Q factor of sensor is calculated as high as 846 and the sensitivity as a biosensor can reach 3. 38 k Hz·cm2/ ng which much higher than that of QCM. Through the antibody detection experiment
the FBAR is proved to have the potential of exhibiting a more crucial effect in the biosensor field.
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