A hybrid microfluidic dehydration chip is reported. The chip is made from glass

polydimethylsiloxane（ PDMS） and polycarbonate（ PC）

the fluid glass substrate and gas PC substrate are irreversibly bonded to an PDMS membrane to respectively form the fluid half chip and gas half chip

putting a layer of porous polytetrafluoroethylene（ PTFE） membrane filter between the two halves

then the gas and fluid halves are reversibly bonded to form a complete glass—PDMS … PDMS—PC chip. This fabrication method is simple and reliable

the fluid half and the gas half are allowed to be replaced individually

so the cost to use can be reduced.The experimental results show good dehydration performance and is expected to be used for efficient dehydration of water-bearing reagent in organic synthesis.